Biomedical Informatics Faculty

Ludmil Alexandrov

Research Focus: Using large-scale omics data to study mutational processes causing human cancer, identifying potential cancer prevention strategies with ML and NLP approaches, and developing novel ML tools for better targeting of cancer treatment.

Tiffany Amariuta

Research Focus: We are a statistical genetics lab focusing on developing methods to study complex traits and polygenic diseases in global populations. We are specifically interested in fine-mapping disease genes and their cell types of action, with the goal of finding targets for gene-based therapeutics.

Ferhat Ay

Research Focus: Epigenetics, genomics, chromatin structure, 3D/4D genome/nucleome, statistical methods for analysis of Hi-C and HiChIP data, gene regulation in immune cells, cancer genomics

Christopher Benner

Research Focus: Transcription, bioinformatics, genomics, innate immunity, chromatin.
We use next-generation sequencing (NGS) and computational analysis to understand the mechanisms responsible for transcription and epigenetic regulation in human development and disease.

Hannah Carter

Research Focus: Genomics and systems biology for precision cancer medicine, variant interpretation, network analysis, immunogenomics

Lukas Chavez

Research Focus: Genomic and Epigenomic Alterations in Childhood Cancers

Chi-Hua Chen

Research Focus: Neuroimaging genetics, neuropsychiatric disorders

Hiutung Chu

Research Focus: host-microbe interactions; gut microbiome; host genetic factors in immunity

Heidi Cook-Andersen

Research Focus: We integrate computational, epigenetic, RNA, and chromatin biology approaches in human, mouse and stem cell models to understand the earliest stages of development -- from the fully differentiated oocyte to the totipotent embryo and successful implantation of the human blastocyst.

Kit Curtius

Research Focus: Mathematical models of cancer evolution, optimization of cancer screening and surveillance, epigenetic aging, translational risk prediction tools

Matteo D'Antonio

Research Focus: Combining genome-wide association studies and polygenic risk scores with environmental variables, lifestyle and social determinants of health to predict disease risk using machine learning and deep learning methods. Using large language models to predict disease

Tal Einav

Research Focus: Antibody-virus interactions, predicting each person's vaccine response, personalized medicine

Robert El-Kareh

Research Focus: Clinical informatics, clinical decision support, diagnostic safety, quality improvement, patient safety

Kelly Frazer

Research Focus: Using iPSCs for genetic analyses, GWAS, QTL analyses, bioinformatic approaches to understanding human disease, single-cell analyses

Terry Gaasterland

Research Focus: Computational Analysis of Human, Novel, and Microbial Genomes: Impact of genetic and evolutionary variation on regulation of transcription and on protein domain structure and function. Causal variants leading to dysregulated cellular response to environmental stresses.

Rodney Gabriel

Research Focus: Perioperative outcomes, pharmacogenomics, machine learning, predictive modeling, regional anesthesia, acute pain.

Fred (Rusty) Gage

Research Focus: Adult central nervous system, Neurogenesis, Modeling neurondegenerative & neuropsychiatric disorders, Neuronal mosaicism & diversity, Human evolution; Somatic retrotransposition, LINE-1, & Alu

Joseph Gleeson

Research Focus: Autism, Whole genome sequencing, Epigenome, Single cell sequencing, Gene-environment interactions, Somatic mosaicism, Systems biology, Protein interactions

Michael Hogarth

Research Focus: Development of next generation public health information systems, terminology/ontology infrastructure in biomedical informatics, and developing systems that support clinical research at the point of care.

Albert Hsiao

Research Focus: Artificial Intelligence, Cardiovascular, COVID-19, x-ray, CT, MRI, Point-of-care Ultrasound

Lilia Iakoucheva

Research Focus: Autism, genetics, gene expression, protein interactions, systems biology, networks, psychiatric diseases, whole genome sequencing

Mohit Jain

Research Focus: Human Biology, Metabolic Biochemistry, Integrative Biology, Mass Spectrometry, Metabolomics

Fay Jiang

Adrian Jinich

Susan Kaech

Research Focus: Understanding how Memory T Cells are produced during infection and vaccination

Kevin King

Research Focus: The King Lab studies diseases in which the immune system becomes activated even though there is no infection, such as heart attacks, metabolic disease, autoimmunity, or cancer. He combines conventional biological methods with novel bioengineering techniques to develop therapies that limit organ dysfunction and promote healing, repair and regeneration.

Jejo Koola

Research Focus: Practicing internist in the field of hospital medicine and clinical informatics. Research focus is on using informatics tools (including predictive analytics, natural language processing, and information visualization) to improve the care of multi-morbid hospital patients.

Pallav Kosuri

Research Focus: The Kosuri Lab studies how movement gives rise to biological function across scales, from molecular motors to muscles. We take a cross-disciplinary approach that makes use of molecular design, computational methods, and functional imaging.

Tsung-Ting Kuo

Research Focus: Blockchain Technologies, Machine Learning, Natural Language Processing

Hojun Li

Research Focus: Multi-omic analysis of human patient samples, functional genomics of stem cells and hematopoiesis, blood disorders and leukemia

Amit Majithia

Research Focus: Insulin resistance, functional genomics, pharmacogenetics, cardiometabolic disease, diabetes

Andrew McCulloch

Research Focus: Multi-scale biology of heart and musculoskeletal system to elucidate the biological principles underlying heart failure, congenital heart disease, arrhythmia and elite human performance

Jill Mesirov

Research Focus: Algorithms and analytic methodologies for pattern recognition and discovery with applications to cancer genomics, to better diagnose, stratify, and treat patients. Development of biologist-friendly biomedical software tools.

Niema Moshiri

Research Focus: Computational viral epidemiology, phylogenetics, models of sequence and tree evolution, Massive Adaptive Interactive Text (MAIT) development

Shamim Nemati

Research Focus: Signal Processing, Dynamical Systems, Multivariate Time Series, Point Process, Deep Learning, Reinforcement Learning, Video Processing, and Natural Language Processing

Lucila Ohno-Machado

Research Focus: Biomedical Informatics, predictive modeling, biomedical data analytics

Bjoern Peters

Research Focus: Immunology, Adapative Immunity, Epitopes, Knowledge Representation, Infectious Disease, Cancer, Allergy, Autoimmunity, Machine Learning, Big Data, Systems Biology

Sandra Sanchez-Roige

Research Focus: Our research aims to advance precision psychiatry using genetic, genomic, medical bioinformatic, and cross-species translational approaches.

Johannes Schoeneberg

Research Focus: Our group uses experimental and computational approaches to study the link between mitochondrial dynamics and neurological diseases that are caused by mitochondrial dysfunction, using 4D adaptive optics lattice light-sheet microscopy, brain organoids, human induced pluripotent stem cells, and machine learning.

Julian Schroeder

Research Focus: Heat and drought resistance mechanisms and network in plants and plant stress signal transduction. Discovery of signaling networks and biological sensors, using systems biological approaches, transcriptomics, proteomics and genome editing.

Jonathan Sebat

Research Focus: Human Genetics, Statistical Genetics, Whole genome sequencing, Long Read Sequencing. Autism, Genetic Therapies for Neurological Disease

Amy Sitapati

Research Focus: Biomedical Informatics, Registries, Population Health, Precision Medicine, Vital Records Informatics, Artificial Intelligence, Quality Informatics, Health Analytics

Pandurangan Vijayanand

Research Focus: Continually evolving genomic tools and single cell analysis technologies are revolutionizing our understanding of the human immune system in health and disease.

Joel Wertheim

Research Focus: Molecular epidemiology of HIV, SARS-CoV-2, and other RNA viruses; Viral phylogenetics and evolution

Dominik Wodarz

Research Focus: Mathematical models of infectious diseases, virus-immune system interactions, carcinogenesis, and cancer therapy; Evolutionary theory and evolutionary dynamics.

Rose Yu

Research Focus: Machine learning, spatiotemporal modeling, deep learning, dynamical systems

Karsten Zengler

Research Focus: Our lab studies microbe-microbe and host-microbe interactions. The goals are i) to predict how complex systems react to perturbations and ii) to design strategies to change the trajectory.