Tumor Cells' Inner Workings Predict Cancer Progression

Using a new assay method to study tumor cells, researchers at the University of California, San Diego School of Medicine and UC San Diego Moores Cancer Center have found evidence of clonal evolution in chronic lymphocytic leukemia (CLL). The assay method distinguishes features of leukemia cells that indicate whether the disease will be aggressive or slow-moving, a key factor in when and how patients are treated.

The findings are published in the July 26, 2012 First Edition online issue of Blood.

Coauthors include two members of the Bioinformatics program: alumnus Han-Yu Chuang, Ph.D. (lead author) and Prof. Trey Ideker.

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