Epigenetic control: slow and global, nimble and local.
|Title||Epigenetic control: slow and global, nimble and local.|
|Publication Type||Journal Article|
|Year of Publication||2008|
|Authors||Cheng CS, Johnson TL, Hoffmann A|
|Date Published||2008 May 1|
|Keywords||Acetylation, Animals, Embryo, Mammalian, Epigenesis, Genetic, Gene Expression Regulation, Developmental, Histone Deacetylases, Mice, Models, Biological, Mutation, NF-kappa B p50 Subunit, Phosphorylation|
The regulation of gene expression involves multiple levels of control, from those that are inheritable to those that are highly responsive to environmental changes. In this issue of Genes & Development, Dong and colleagues (pp. 1159-1173) demonstrate that the dynamically controlled immune response transcription factor NF-kappaB may, in fact, have a role in regulating heterochromatin and gene expression at large distances from its actual target sequences and genes.
|Alternate Title||Genes Dev.|