Microinversions in mammalian evolution.

TitleMicroinversions in mammalian evolution.
Publication TypeJournal Article
Year of Publication2006
AuthorsChaisson MJ, Raphael BJ, Pevzner PA
JournalProc Natl Acad Sci U S A
Volume103
Issue52
Pagination19824-9
Date Published2006 Dec 26
ISSN0027-8424
KeywordsAnimals, Biological Evolution, Computational Biology, Genetic Vectors, Humans, Mammals
Abstract

We propose an approach for identifying microinversions across different species and show that microinversions provide a source of low-homoplasy evolutionary characters. These characters may be used as "certificates" to verify different branches in a phylogenetic tree, turning the challenging problem of phylogeny reconstruction into a relatively simple algorithmic problem. We estimate that there exist hundreds of thousands of microinversions in genomes of mammals from comparative sequencing projects, an untapped source of new phylogenetic characters.

DOI10.1073/pnas.0603984103
PubMed URLhttp://www.ncbi.nlm.nih.gov/pubmed/17189424?dopt=Abstract
PMCPMC1750909
Alternate TitleProc. Natl. Acad. Sci. U.S.A.
PubMed ID17189424