Discovering regulated networks during HIV-1 latency and reactivation.

TitleDiscovering regulated networks during HIV-1 latency and reactivation.
Publication TypeJournal Article
Year of Publication2006
AuthorsBandyopadhyay S, Kelley R, Ideker T
JournalPac Symp Biocomput
Pagination354-66
Date Published2006
ISSN1793-5091
KeywordsAlgorithms, Cell Line, Cluster Analysis, Computational Biology, Gene Expression Profiling, HIV Infections, HIV-1, Humans, Oligonucleotide Array Sequence Analysis, Virus Activation, Virus Latency
Abstract

Human immunodeficiency virus (HIV) affects millions of people across the globe. Despite the introduction of powerful anti-viral therapies, one factor confounding viral elimination is the ability of HIV to remain latent within the host genome. Here, we perform a network analysis of the viral reactivation process using human gene expression profiles and curated databases of both human-human and human-HIV protein interactions. Based on this analysis, we report the identification of active pathways in both the latent and early phases of reactivation. These active pathways suggest host functions that are altered and important for HIV pathogenesis.

PubMed URLhttp://www.ncbi.nlm.nih.gov/pubmed/17094252?dopt=Abstract
Publisher URLhttp://psb.stanford.edu/psb-online/proceedings/psb06/bandyopadhyay.pdf
Alternate TitlePac Symp Biocomput
PubMed ID17094252