Comparison of network-based pathway analysis methods.
|Title||Comparison of network-based pathway analysis methods.|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Papin JA, Stelling J, Price ND, Klamt S, Schuster S, Palsson BO|
|Date Published||2004 Aug|
|Keywords||Algorithms, Computational Biology, Erythrocytes, Helicobacter pylori, Humans, Signal Transduction|
Network-based definitions of biochemical pathways have emerged in recent years. These pathway definitions insist on the balanced use of a whole network of biochemical reactions. Two such related definitions, elementary modes and extreme pathways, have generated novel hypotheses regarding biochemical network function. The relationship between these two approaches can be illustrated by comparing and contrasting the elementary modes and extreme pathways of previously published metabolic reconstructions of the human red blood cell (RBC) and the human pathogen Helicobacter pylori. Descriptions of network properties generated by using these two approaches in the analysis of realistic metabolic networks need careful interpretation.
|Alternate Title||Trends Biotechnol.|