Identifying constraints that govern cell behavior: a key to converting conceptual to computational models in biology?

TitleIdentifying constraints that govern cell behavior: a key to converting conceptual to computational models in biology?
Publication TypeJournal Article
Year of Publication2003
AuthorsCovert MW, Famili I, Palsson BO
JournalBiotechnol Bioeng
Volume84
Issue7
Pagination763-72
Date Published2003 Dec 30
ISSN0006-3592
KeywordsAdaptation, Physiological, Cell Communication, Cell Division, Cell Physiological Phenomena, Environment, Evolution, Molecular, Models, Biological, Signal Transduction
Abstract

Cells must abide by a number of constraints. The environmental constrains of cellular behavior and physicochemical limitations affect cellular processes. To regulate and adapt their functions, cells impose constraints on themselves. Enumerating, understanding, and applying these constraints leads to a constraints-based modeling formalism that has been helpful in converting conceptual models to computational models in biology. The continued success of the constraints-based approach depends upon identification and incorporation of new constraints to more accurately define cellular capabilities. This review considers constraints in terms of environmental, physicochemical, and self-imposed regulatory and evolutionary constraints with the purpose of refining current constraints-based models of cell phenotype.

DOI10.1002/bit.10849
PubMed URLhttp://www.ncbi.nlm.nih.gov/pubmed/14708117?dopt=Abstract
Alternate TitleBiotechnol. Bioeng.
PubMed ID14708117